In situ tumour arrays reveal early environmental control of cancer immunity.

doi:10.1038/s41586-023-06132-2

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Article

In situ tumour arrays reveal early environmental control of cancer immunity.

Nature - 1 Jun 2023

Ortiz-Muñoz Guadalupe, Brown Markus, Carbone Catherine B, Pechuan-Jorge Ximo, Rouilly Vincent, Lindberg Henrik, Ritter Alex T, Raghupathi Gautham, Sun Qianbo, Nicotra Tess, Mantri Shreya R, Yang Angela, Doerr Jonas, Nagarkar Deepti, Darmanis Spyros, Haley Benjamin, Mariathasan Sanjeev, Wang Yulei, Gomez-Roca Carlos, de Andrea Carlos Eduardo, Spigel David, Wu Thomas, Delamarre Lelia, Schöneberg Johannes, Modrusan Zora, Price Richard, Turley Shannon J, Mellman Ira, Moussion Christine

Abstract excerpt

The immune phenotype of a tumour is a key predictor of its response to immunotherapy1-4. Patients who respond to checkpoint blockade generally present with immune-inflamed5-7 tumours that are highly infiltrated by T cells. However, not all inflamed tumours respond to therapy, and even lower response rates occur among tumours that lack T cells (immune desert) or that spatially exclude T cells to the periphery of...

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Identifiers

PMID: 37258670
DOI: 10.1038/s41586-023-06132-2
PMCID: PMC10284705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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