Back to search

Article

Spatial remodeling of the urothelial carcinoma tumor microenvironment shapes response to neoadjuvant atezolizumab

2026-04-20

Abstract excerpt

<h4>ABSTRACT</h4> The ABACUS study was a single arm, phase II trial evaluating neoadjuvant atezolizumab in operable urothelial carcinoma. Initial bulk transcriptomic and immunohistochemistry analyses suggested links between immune activation, tissue remodeling, and resistance pathways such as transforming growth factor β that were associated with clinical outcome. To further characterize spatial and phenotypic ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
13a7bb90-8dfd-528a-a34d-9f21cd09a3b1
DOI
10.64898/2026.04.15.26350980
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatial remodeling of the urothelial carcinoma tumor microenvironment shapes response to neoadjuvant atezolizumabDOI 10.64898/2026.04.15.26350980
Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironmentSemantic proximity
Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancerSemantic proximity
Multi-omics characterization of cellular state diversity and bidirectional tumor-stroma/immune interactions in cervical squamous cell carcinomaSemantic proximity
A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV statusSemantic proximity
SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial CarcinomaSemantic proximity
A spatially resolved whole-layers landscape of bladder cancer deciphers dynamic invasive progressionSemantic proximity
Spatial Transcriptomic Profiling Uncovers Tumor Heterogeneity and Microenvironmental Features Associated with Lymph Node Metastasis in Invasive Lobular CarcinomaSemantic proximity
Integrative Spatial Analysis of H&E and IHC Images Identifies Prognostic Immune Subtypes Correlated with Progression-Free Survival in Human Papillomavirus (HPV)-Related Oropharyngeal Squamous Cell CarcinomaSemantic proximity
Spatial tumor immune microenvironment phenotypes in ovarian cancerSemantic proximity
Spatial biomarkers of response to neoadjuvant therapy in muscle-invasive bladder cancer: the DUTRENEO trialSemantic proximity
The landscape of tertiary lymphoid structures in endometrial cancer revealed through harmonized multi-level transcriptomicsSemantic proximity
Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study.Semantic proximity
Select a neighboring publication to make it the new centre.