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GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers

2023-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the cellular mechanisms of novel immunotherapy agents in the human tumor microenvironment ( TME ) is critical to their clinical success. We examined GITR and TIGIT immunotherapy in gastric and colon cancer patients using ex vivo slice tumor slice cultures derived from cancer surgical resections. This primary culture system maintains the original TME in a near-native state. We app...

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Identifiers and source

Literature Corpus work
dc288f9b-e681-5f9a-af3f-c316b9ec4cff
DOI
10.1101/2023.03.13.532299
Open publication

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GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancersDOI 10.1101/2023.03.13.532299
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