Article
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Immunity - 15 Dec 2020
Bonavita Eduardo, Bromley Christian P, Jonsson Gustav, Pelly Victoria S, Sahoo Sudhakar, Walwyn-Brown Katherine, Mensurado Sofia, Moeini Agrin, Flanagan Eimear, Bell Charlotte R, Chiang Shih-Chieh, Chikkanna-Gowda C P, Rogers Neil, Silva-Santos Bruno, Jaillon Sebastien, Mantovani Alberto, Reis e Sousa Caetano, Guerra Nadia, Davis Daniel M, Zelenay Santiago
Abstract excerpt
Inflammation can support or restrain cancer progression and the response to therapy. Here, we searched for primary regulators of cancer-inhibitory inflammation through deep profiling of inflammatory tumor microenvironments (TMEs) linked to immune-dependent control in mice. We found that early intratumoral accumulation of interferon gamma (IFN-γ)-producing natural killer (NK) cells induced a profound remodeling of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.