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Article

Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments.

Thorax - 1 Nov 2020

Kanellakis Nikolaos I, Asciak Rachelle, Hamid Megat Abd, Yao Xuan, McCole Mark, McGowan Simon, Seraia Elena, Hatch Stephanie, Hallifax Rob J, Mercer Rachel M, Bedawi Eihab O, Jones Stephanie, Verrill Clare, Dobson Melissa, George Vineeth, Stathopoulos Georgios T, Peng Yanchun, Ebner Daniel, Dong Tao, Rahman Najib M, Psallidas Ioannis

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32943495
DOI: 10.1136/thoraxjnl-2020-215027
PMCID: PMC7569377

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