Article
The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.
PLoS biology - 1 Sept 2018
Knoblich Konstantin, Cruz Migoni Sara, Siew Susan M, Jinks Elizabeth, Kaul Baksho, Jeffery Hannah C, Baker Alfie T, Suliman Muath, Vrzalikova Katerina, Mehenna Hisham, Murray Paul G, Barone Francesca, Oo Ye H, Newsome Philip N, Hirschfield Gideon, Kelly Deirdre, Lee Steven P, Parekkadan Biju, Turley Shannon J, Fletcher Anne L
Abstract excerpt
The microenvironment of lymphoid organs can aid healthy immune function through provision of both structural and molecular support. In mice, fibroblastic reticular cells (FRCs) create an essential T-cell support structure within lymph nodes, while human FRCs are largely unstudied. Here, we show that FRCs create a regulatory checkpoint in human peripheral T-cell activation through 4 mechanisms simultaneously...
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