Article

CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

2022-07-02

Abstract excerpt

The APOE4 allele increases the risk for Alzheimer’s disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of murine APOE with human APOE3 or APOE4 , the latter show reduced neuronal dendritic complexity and impaired learning. APOE4 TR mice also show reduced gamma oscillation power and sharp wave rippl...

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Literature Corpus work: e612bc55-9e13-50f6-8c52-fb54fd48aae8
DOI: 10.1101/2022.06.29.498148

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CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement miceDOI 10.1101/2022.06.29.498148Read

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