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Article

Targeting CCL5 signaling attenuates neuroinflammation after seizure

28 Nov 2022

Abstract excerpt

BACKGROUND: Epilepsy is a neurological condition that causes unprovoked, recurrent seizures. Accumulating evidence from clinical and experimental studies indicates that neuroinflammation exacerbates seizure activity. METHODS: We investigated the transcriptional changes occurring in specific brain domains of a seizure mouse model, using 10× Genomics spatial transcriptomics. Differential gene expression and pathway...

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PMID: 36440924
DOI: 10.1111/cns.14006

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