Article
Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice.
Molecular psychiatry - 1 Aug 2022
Giannisis Andreas, Patra Kalicharan, Edlund Anna K, Nieto Lur Agirrezabala, Benedicto-Gras Joan, Moussaud Simon, de la Rosa Andrés, Twohig Daniel, Bengtsson Tore, Fu Yuan, Bu Guojun, Bial Greg, Foquet Lander, Hammarstedt Christina, Strom Stephen, Kannisto Kristina, Raber Jacob, Ellis Ewa, Nielsen Henrietta M
Abstract excerpt
Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer's disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenotype promotes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.