Article

The Alzheimer’s disease risk factor APOE4 drives pro-inflammation in human astrocytes <i>via</i> HDAC-dependent repression of TAGLN3

2021-04-16

Abstract excerpt

<h4>ABSTRACT</h4> The Apolipoprotein E4 ( APOE4 ) is the major allelic risk factor for late-onset Alzheimer’s disease (AD). APOE4 associates with a pro-inflammatory phenotype increasingly considered as critical in AD initiation and progression. Yet, the mechanisms driving an APOE4-dependent neuroinflammation remain unelucidated. Leveraging patient specific human induced Pluripotent Stem Cells (iPSCs) we demonstr...

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Literature Corpus work: b8ae8170-7a5c-5093-a739-3168727dff1c
DOI: 10.1101/2021.04.16.440108

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