Article

Inter-homologue repair in fertilized human eggs?

2017-08-28

Abstract excerpt

Many human diseases have an underlying genetic component. The development and application of methods to prevent the inheritance of damaging mutations through the human germline could have significant health benefits, and currently include preimplantation genetic diagnosis and carrier screening. Ma et al. take this a step further by attempting to remove a disease mutation from the human germline through gene editin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6022f8a-6311-581d-8034-7e21b1a2c8e6
DOI: 10.1101/181255

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inter-homologue repair in fertilized human eggs?DOI 10.1101/181255Read

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair.Semantic proximity Read

Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryosSemantic proximity Read

Early post-zygotic mutations contribute to congenital heart diseaseSemantic proximity Read

Efficient Zygotic Genome Editing via RAD51-Enhanced Interhomolog RepairSemantic proximity Read

FREQUENT GENE CONVERSION IN HUMAN EMBRYOS INDUCED BY DOUBLE STRAND BREAKSSemantic proximity Read

Donor-Free Gene Correction by Targeted Interhomolog RecombinationSemantic proximity Read

Correction of a pathogenic gene mutation in human embryos.Semantic proximity Read

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos.Semantic proximity Read

Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatallySemantic proximity Read

Missed connections: recombination and human aneuploidySemantic proximity Read

The origins of genetic variation between individual human oocytes and embryos: implications for infertility.Semantic proximity Read

Transmission distortion affecting human noncrossover but not crossover recombination: a hidden source of meiotic drive.Semantic proximity Read