Article

Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally

2021-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Humans present remarkable mitochondrial DNA (mtDNA) variant mosaicism, not only across tissues but even across individual cells within one person. The timing of the first appearance of this mosaicism has not yet been established. In this study, we hypothesized it occurs during preimplantation development. To investigate this, we deep-sequenced the mtDNA of 254 oocytes from 85 donors, 158 single...

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Literature Corpus work: 2a001d7a-3fd0-5d6a-b03a-2e5ca6d6c5f4
DOI: 10.1101/2021.11.05.467445

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