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Article

Missed connections: recombination and human aneuploidy

23 Jan 2021

Abstract excerpt

The physical exchange of DNA between homologs, crossing-over, is essential to orchestrate the unique, reductional first meiotic division (MI). In females, the events of meiotic recombination that serve to tether homologs and facilitate their disjunction at MI occur during fetal development, preceding the MI division by several decades in our species. Data from studies in humans and mice demonstrate that placement...

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PMID: 33484483
DOI: 10.1002/pd.5910

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