Article

Early post-zygotic mutations contribute to congenital heart disease

2019-08-13

Abstract excerpt

<h4>Background</h4> The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tissue has not been determined. <h4>Results</h4> We developed a computational method, Expectation-Maximization-based detection of Mosaicism (EM-mosaic), to analyze mosai...

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Literature Corpus work: 2f2463e7-a30d-5187-b9cd-b7feed4ea9d3
DOI: 10.1101/733105

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