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Article

Regulation of cytoplasmic dynein ATPase by Lis1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2006

Mesngon Mariano T, Tarricone Cataldo, Hebbar Sachin, Guillotte Aimee M, Schmitt E William, Lanier Lorene, Musacchio Andrea, King Stephen J, Smith Deanna S

Abstract excerpt

Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate neuronal migration and other motile events. Yeast two-hybrid studies...

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Identifiers

PMID: 16481446
DOI: 10.1523/JNEUROSCI.5095-05.2006
PMCID: PMC4399971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of cytoplasmic dynein ATPase by Lis1.PMID 16481446Read ↗

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Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1Semantic proximity Read ↗

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Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedgeSemantic proximity Read ↗

The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.Semantic proximity Read ↗

Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].Semantic proximity Read ↗

LIS1 and dynein motor function in neuronal migration and development.Semantic proximity Read ↗

Structures of human cytoplasmic dynein in complex with the lissencephaly 1 protein, LIS1Semantic proximity Read ↗

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedgeSemantic proximity Read ↗

Nde1 Promotes Lis1-Mediated Activation of DyneinSemantic proximity Read ↗

[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein].Semantic proximity Read ↗

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