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SIRT2 suppressed osteogenesis via transcriptionally regulation of SLC31A1-meidated cuproptosis in a crotonylation manner

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Osteoporosis (OP), a systemic disorder of bone metabolism characterized by impaired osteogenesis and excessive skeletal resorption, is increasingly linked to epigenetic regulation. Among these, histone crotonylation (Kcr) has emerged as a key determinant of gene expression and cellular differentiation, yet the role of histone H3 lysine 4 crotonylation (H3K4cr) in osteogenesis remains un...

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Literature Corpus work
e5f8fa21-03d8-5361-843f-3cf3a4fdd9aa
DOI
10.21203/rs.3.rs-7734583/v1
Open publication

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SIRT2 suppressed osteogenesis via transcriptionally regulation of SLC31A1-meidated cuproptosis in a crotonylation mannerDOI 10.21203/rs.3.rs-7734583/v1
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