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Article

Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis.

Experimental & molecular medicine - 1 Jan 2023

Jin Runze, Zhang Hanshu, Lin Chujiao, Guo Jinqiang, Zou Weiguo, Chen Zhi, Liu Huan

Abstract excerpt

Haploinsufficiency of Runt-related transcription factor-2 (RUNX2) is responsible for cleidocranial dysplasia (CCD), a rare hereditary disease with a range of defects, including delayed closure of the cranial sutures and short stature. Symptom-based treatments, such as a combined surgical-orthodontic approach, are commonly used to treat CCD patients. However, there have been few reports of treatments based on...

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PMID: 36599929
DOI: 10.1038/s12276-022-00914-w
PMCID: PMC9898552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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