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Article

Targeted disruption of PRC1.1 complex enhances bone remodeling

8 May 2025

Abstract excerpt

Polycomb repressive complexes (PRCs) are pivotal epigenetic regulators that preserve cell identity by restricting transcription responses to sub-threshold extracellular signals. Their roles in osteoblast function and bone formation remain unclear. Here in aging osteoblasts, we found marked activation of PRC1.1 complex, with KDM2B acting as a chromatin-binding factor and BCOR and PCGF1 enabling histone H2A...

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PMID: 40341537
DOI: 10.1038/s41467-025-59638-w

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