Article
The Role of FoxOs in Bone Health and Disease.
Current topics in developmental biology - 1 Jan 2018
Kim Ha-Neui, Iyer Srividhya, Ring Rebecca, Almeida Maria
Abstract excerpt
Recent studies with murine models of cell-specific loss- or gain-of-function of FoxOs have provided novel insights into the function and signaling of these transcription factors on the skeleton. They have revealed that FoxO actions in chondrocytes are critical for normal skeletal development, and FoxO actions in cells of the osteoclast or osteoblast lineage greatly influence bone resorption and formation and,...
Topics
- Animals
- Bone Resorption
- Bone and Bones
- Forkhead Transcription Factors
- Humans
- Mutation
- Osteoblasts
- Osteoclasts
- Osteogenesis
- Signal Transduction