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Article

Post-translational Regulation of Runx2 in Bone and Cartilage

1 Aug 2009

Abstract excerpt

The Runx2 gene product is essential for mammalian bone development. In humans, Runx2 haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by bone and dental abnormalities. At the molecular level, Runx2 acts as a transcription factor for genes expressed in hypertrophic chondrocytes and osteoblasts. Runx2 gene expression and protein function are regulated on multiple levels,...

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PMID: 19734454
DOI: 10.1177/0022034509341629

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