Article

The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

2021-01-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal cells (MSCs) are reasonable precursor cell candidates of cartilaginous tumors. This study aimed to investigate the effect of oncometa...

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Literature Corpus work: 2bafd36f-6532-528a-83a2-fe7b5d256f0e
DOI: 10.21203/rs.3.rs-18260/v3

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