Article

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

2024-05-07

Abstract excerpt

<title>Abstract</title> <p>Osteoporosis (OP) is a common and fracture-prone skeletal disease featured by deteriorated trabecular microstructure and pathologically involves various forms of regulated bone cell death. However, the role and regulatory mechanisms of ferroptosis in OP are not fully understood. Our study showed marked iron deposition, ferroptosis, and a core anti-ferroptotic factor GPX4 (glutathione pe...

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Literature Corpus work: 545017ed-500c-50fd-96c5-de882c9e8bbe
DOI: 10.21203/rs.3.rs-4301039/v1

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