Inhibition of ACSS2-mediated H3K9 crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence

Abstract excerpt

<title>Abstract</title> <p>Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone Kcr of tubular epithelial cells was significantly elevated in fibrotic kidneys. By screening these crotonylated/acetylated factors, a crotonyl-CoA-producing enzyme—ACSS2 (acyl-CoA synthetase short ch...

Topics

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• 14-3-3 protein interactions
• Chronic Kidney Disease and Diabetes
• Epigenetics and DNA Methylation
• Liver Disease Diagnosis and Treatment
• Peptidase Inhibition and Analysis
• Renal Diseases and Glomerulopathies
• Signaling Pathways in Disease
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

e28ef3be-709a-5b71-9fe5-6e551fed6fa9

DOI

10.21203/rs.3.rs-3026608/v1