Article

Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis

2026-07-27

Abstract excerpt

Skeletal and mesenchymal cells have limited bone-forming potential due to their rarity, tendency for senescence and/or unstable osteogenic lineage commitment. We previously identified an osteopotent CXCR4⁺ stem cell population with unclear mechanism for its differentiation potential. Here, we found that the cystine transporter SLC3A1 was selectively enriched in CXCR4 + stem cells, uncovering a role for amino acid...

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Literature Corpus work: 80d8051a-a928-53a1-b853-8f8c428f3f3a
DOI: 10.64898/2026.07.25.740706

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