Article

Enhancer profiling identifies RXRα as a key suppressor of nephrolithiasis-promoting genes in calcium oxalate kidney stone disease

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>During the formation of kidney stones, the interaction between stone crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, triggering osteogenic transformation and inflammatory responses. However, the molecular mechanisms underlying these changes in TECs remain elusive. Through high-throughput drug screening, we identified JQ1, an enhancer targeting epige...

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Literature Corpus work: 6c396777-86bc-580e-a8ab-37962ac1ef0c
DOI: 10.21203/rs.3.rs-3897770/v1

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