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Membrane Proteome Remodeling in Female APP Mice Following Muscarinic Acetylcholine Receptor M1 Modulation Revealed by Peptidisc Enabled DIA-MS

2026-02-26

Abstract excerpt

Alzheimer’s disease (AD) is linked to profound dysregulation of membrane-embedded and membrane-associated proteins that govern amyloid processing, synaptic signaling, and neuronal communication. Yet most proteomic analyses prioritize soluble fractions, resulting in systematic underrepresentation of integral membrane proteins and limited access to disease-relevant membrane pathways. Here, we use a membrane-mimetic,...

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Literature Corpus work
e5e785ce-6225-5482-a928-c72a66a3411d
DOI
10.64898/2026.02.24.707828
Open publication

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Membrane Proteome Remodeling in Female APP Mice Following Muscarinic Acetylcholine Receptor M1 Modulation Revealed by Peptidisc Enabled DIA-MSDOI 10.64898/2026.02.24.707828
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