Article

Ts65Dn synaptic proteome partially recapitulates AD biochemical signature

2023-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS), caused by human chromosome 21 trisomy, is one of the most common genetic causes of intellectual disabilities. Moreover, approximately 60-80% of individuals with Down Syndrome develop early onset Alzheimer’s disease symptoms and neuropathology characterized by the deposition of senile plaques and neurofibrillary tangles. Spine loss and synaptic deficits are the main alteration...

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Literature Corpus work: 3281cab8-526a-571d-b13e-a2fdd348f6ec
DOI: 10.1101/2023.04.25.538253

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