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Coupling CZE, liquid-phase ion mobility, to MS/MS for quantitative top-down proteomics: revealing significant proteoform differences between healthy and Alzheimer’s disease brains

2025-07-07

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression. Here we present one of the first quantitative top-down proteomics (TDP) studies of postmortem cortex samples fro...

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Literature Corpus work: 8cdf61b1-7fd7-508f-800f-611072dd73c2
DOI: 10.22541/au.175189892.25635101/v1

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