Article

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MS

2026-07-19

Abstract excerpt

One of the defining features of neurons is their compartmentalisation into soma, dendrites and axon. Axons are highly specialised for the transmission of signals over long distances but also exhibit unique vulnerabilities in the context of neurodegeneration, implying a specialised axonal proteome. However, in-depth proteomic characterisation of axons has been limited by the difficulty of isolating pure axonal mate...

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Literature Corpus work: 6acde614-fbc0-58f0-94c7-b78c24231928
DOI: 10.64898/2026.07.17.739061

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