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Age-dependent brain proteome remodeling links <i>Abca7</i> deficiency to insulin signaling and neuroinflammation in Alzheimer’s disease mice

2026-07-31

Abstract excerpt

The human ABCA7 gene, which encodes ATP-binding cassette transporter A7 (ABCA7), is one of the strongest genetic risk factors for late-onset Alzheimer’s disease (AD), yet the molecular mechanisms linking ABCA7 deficiency to AD remain incompletely understood. Because impaired insulin signaling and neuroinflammation are increasingly recognized as key contributors to AD pathogenesis, and ABCA7 has been implicated in...

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Literature Corpus work
4fd78174-2771-5f3b-bcde-5654941bf33e
DOI
10.64898/2026.07.28.741021
Open publication

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Age-dependent brain proteome remodeling links <i>Abca7</i> deficiency to insulin signaling and neuroinflammation in Alzheimer’s disease miceDOI 10.64898/2026.07.28.741021
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