Article

Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function

2020-05-03

Abstract excerpt

<h4>SUMMARY</h4> Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause Neuronal Ceroid Lipofuscinosis type 1 ( CLN1 ), a devastating neurodegenerative disease. Here, we provide a resource identifying PPT1 substrates. We utilized Acyl Resin-Assisted Capture and mass spectrometry to identify proteins with increased in vivo palmitoylation in PPT1 knockout mouse bra...

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Literature Corpus work: 54220678-a6bc-5a3e-b5de-9c8524decc5f
DOI: 10.1101/2020.05.02.074302

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