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Synaptic proteomics reveal distinct molecular signatures of cognitive change and<i>C9ORF72</i>repeat expansion in the human ALS cortex

2022-06-14

Abstract excerpt

The two major hypotheses of Amyotrophic Lateral Sclerosis (ALS) pathogenesis (dying-forward and dying-back) have synapses at their core. Furthermore, increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in ALS. Despite this, we still know very little about the molecular profile of an ALS synapse. To address this gap, we designed a synaptic proteomics experiment to perform a...

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Literature Corpus work
db822d37-ae69-5ffe-ae8d-e806c63ee04e
DOI
10.1101/2022.06.10.22276194
Open publication

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Synaptic proteomics reveal distinct molecular signatures of cognitive change and<i>C9ORF72</i>repeat expansion in the human ALS cortexDOI 10.1101/2022.06.10.22276194
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