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Investigation of Neurons and Microglia from <i>APOE3</i> Induced Pluripotent Stem Cells using Data-Independent Acquisitions on a ZenoTOF 7600

2025-11-04

Abstract excerpt

Induced pluripotent stem cell (iPSC)-derived neurons and microglia are valuable human models for studying neurodegenerative diseases. Specifically, the apolipoprotein E4 ( APOE4 ) gene is a major genetic risk factor for late-onset Alzheimer’s disease. Apolipoprotein E ( APOE ) alleles E2, E3 and E4 can be beneficial, neutral, or increase the risk of Alzheimer’s disease (AD). Here, we developed a proteomic workfl...

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Literature Corpus work
c27cf9cf-fd56-575c-92d1-58bc9874138f
DOI
10.1101/2025.11.02.686128
Open publication

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Investigation of Neurons and Microglia from <i>APOE3</i> Induced Pluripotent Stem Cells using Data-Independent Acquisitions on a ZenoTOF 7600DOI 10.1101/2025.11.02.686128
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