Back to search

Article

A dysregulated stromal remodelling programme characterises prior anti-TNF failure in ulcerative colitis

2026-08-12

Abstract excerpt

Prior anti-tumour necrosis factor (TNF) failure is associated with reduced efficacy of subsequent advanced therapies in ulcerative colitis (UC), but the biological basis of this treatment-refractory state remains unclear. We integrated clinical outcomes and baseline colonic transcriptomic data from UC patients in the UNIFI phase III trial programme with regulatory and signalling network inference, connectivity map...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e5c25b89-3325-5c7d-b02c-b79a73e9967c
DOI
10.64898/2026.08.11.744139
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A dysregulated stromal remodelling programme characterises prior anti-TNF failure in ulcerative colitisDOI 10.64898/2026.08.11.744139
Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitisSemantic proximity
A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel diseaseSemantic proximity
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel diseaseSemantic proximity
Cytokine interaction networks, not individual cytokines, drive anti-TNF response in Crohn’s diseaseSemantic proximity
Decoding Cytokine Networks in Ulcerative Colitis to Identify Pathogenic Mechanisms and Therapeutic TargetsSemantic proximity
A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel diseaseSemantic proximity
The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response MechanismsSemantic proximity
A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s diseaseSemantic proximity
Single-cell analysis of an adult IBD INCEPTION cohort reveals Galectin-linked disease mechanismsSemantic proximity
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healingSemantic proximity
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel DiseaseSemantic proximity
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.