Article

The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response Mechanisms

2022-05-18

Abstract excerpt

<h4>Background and Aims</h4> JAK1 inhibitor upadacitinib and IL23 inhibitor risankizumab are efficacious in inflammatory bowel disease (IBD) patients who are anti-TNFα inadequate responders (TNF-IR). We aimed to understand the mechanisms mediating the response of upadacitinib and risankizumab. <h4>Methods</h4> Eight tissue transcriptomic datasets from IBD patients treated with anti-TNFα therapies along with sing...

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Literature Corpus work: fa4919cb-31c8-5e4e-b152-aa5b7f0eff27
DOI: 10.1101/2022.05.16.492167

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