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A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s disease

2026-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Despite major advances in immunotherapies, durable disease control in immune-mediated inflammatory diseases (IMIDs) is frequently limited by resistance driven by maladaptive immune programs, resulting in progressive tissue damage. Myeloid cells are central effectors across IMIDs, including inflammatory bowel disease (IBD), yet how discrete myeloid states govern disease progression and therapeuti...

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Literature Corpus work
bc83eefb-ea87-5d22-8632-bcbccbe4381a
DOI
10.64898/2026.02.12.705345
Open publication

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