Back to search

Article

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

2021-02-06

Abstract excerpt

Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology, and in situ localisation, we describe heterogeneity of the tissular inflammatory response in IBD treatment failure. Among inflammatory pathotypes, we found high neutrophil infiltration, activation of fibroblasts, and vascular remodelling...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d0cebb6e-bdfc-56b1-b046-224035a9901c
DOI
10.1101/2021.02.05.429804
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel diseaseDOI 10.1101/2021.02.05.429804
Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity
Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitisSemantic proximity
A dysregulated stromal remodelling programme characterises prior anti-TNF failure in ulcerative colitisSemantic proximity
A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s diseaseSemantic proximity
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity
Molecular characterization of response to etrolizumab and anti-TNF reveals treatment resistance in ulcerative colitis is associated with an abundance of residual neutrophil subsets and inflammatory fibroblast populationsSemantic proximity
Assessing Cellular and Transcriptional diversity of IIeal Mucosa amongst Treatment Naïve and Treated Crohn’s diseaseSemantic proximity
Single-cell analysis of an adult IBD INCEPTION cohort reveals Galectin-linked disease mechanismsSemantic proximity
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitisSemantic proximity
A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel diseaseSemantic proximity
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healingSemantic proximity
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity
Select a neighboring publication to make it the new centre.