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Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitis

2026-06-10

Abstract excerpt

Mucosal healing (MH) is the primary therapeutic endpoint in ulcerative colitis (UC), yet frequent relapses suggest it does not reflect complete tissue recovery. To define the basis of this vulnerability, we generated a multimodal atlas of UC integrating single-cell and bulk transcriptomics, Visium HD spatial profiling, and multiplexed imaging across 89 patients. We show that MH represents a distinct biological sta...

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Literature Corpus work
95cc99ea-986e-5509-9cf5-87789272844d
DOI
10.64898/2026.06.09.730670
Open publication

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Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitisDOI 10.64898/2026.06.09.730670
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