Article

Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease

2025-01-28

Abstract excerpt

<h4>Background and Aims</h4> Total abdominal colectomy (TAC) with a staged ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative colitis (UC). However, a significant percentage of patients experience pouch failure, leading to morbidity. This retrospective case-control study identified histopathological features of the TAC specimen associated with pouch failure and investigated the mole...

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Literature Corpus work: a411b7af-7c69-548d-ab0d-933307840a99
DOI: 10.1101/2025.01.27.635092

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