Article

Cytokine interaction networks, not individual cytokines, drive anti-TNF response in Crohn’s disease

2026-08-11

Abstract excerpt

Crohn’s disease (CD) is a chronic inflammatory condition of the gastrointestinal tract for which anti-tumour necrosis factor (anti-TNF) agents remain a first-line biologic therapy. However, remission rates are modest, and the mechanistic basis of non-response is poorly characterised. A common resistance mechanism is thought to emerge when alternative inflammatory cascades compensate for TNF inhibition, but the int...

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Literature Corpus work: 3d1b0927-5fac-59af-8edb-63e6428d6648
DOI: 10.64898/2026.08.11.744137

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