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Article

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing

27 Jan 2022

Abstract excerpt

Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular circuits driving extracellular matrix deposition and remodeling stands to illuminate the relationship between inflammation, fibrosis, and healing. We performed...

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PMID: 35085231
DOI: 10.1371/journal.pbio.3001532

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