Article

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

2023-05-06

Abstract excerpt

Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires an understanding of how cellular networks change following therapy. We describe a therapeutic atlas for Crohn’s disease (CD) and ulcerative colitis (UC) following anti-tumour necrosis factor (TNF) therapy. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies from 38 patients and three c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be124ba5-ffa4-576a-9660-8ddadded40d4
DOI: 10.1101/2023.05.05.539635

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel diseaseDOI 10.1101/2023.05.05.539635Read

Cytokine interaction networks, not individual cytokines, drive anti-TNF response in Crohn’s diseaseSemantic proximity Read

Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory DiseasesSemantic proximity Read

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read

Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockadeSemantic proximity Read

The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response MechanismsSemantic proximity Read

Characterizing cellular subpopulations critical to treatment response in autoimmune diseasesSemantic proximity Read

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s diseaseSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Decoding Cytokine Networks in Ulcerative Colitis to Identify Pathogenic Mechanisms and Therapeutic TargetsSemantic proximity Read