Article

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer’s Disease

2025-02-01

Abstract excerpt

Alzheimer’s Disease (AD) is marked by the accumulation of pathology, neuronal loss, and gliosis and frequently accompanied by cognitive decline. Understanding brain cell interactions is key to identifying new therapeutic targets to slow its progression. Here, we used systems biology methods to analyze single-nucleus RNA sequencing (snRNASeq) data generated from dorsolateral prefrontal cortex (DLPFC) tissues of 424...

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Literature Corpus work: e5a90396-ad7d-584c-9032-b470e1e8916c
DOI: 10.1101/2025.01.31.635970

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