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Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer’s disease

12 Aug 2020

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in cell-type proportions and consequently marked alterations of the transcriptome. Here we use a data-driven systems biology meta-analytical approach across three human AD cohorts, encompassing six cortical brain regions, and integrate with multi-scale datasets comprising of DNA methylation, histone acetylation,...

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PMID: 32803238
DOI: 10.1093/hmg/ddaa182

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