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Article

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.

Genome medicine - 1 Nov 2016

Wang Minghui, Roussos Panos, McKenzie Andrew, Zhou Xianxiao, Kajiwara Yuji, Brennand Kristen J, De Luca Gabriele C, Crary John F, Casaccia Patrizia, Buxbaum Joseph D, Ehrlich Michelle, Gandy Sam, Goate Alison, Katsel Pavel, Schadt Eric, Haroutunian Vahram, Zhang Bin

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidate molecular systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain...

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Identifiers

PMID: 27799057
DOI: 10.1186/s13073-016-0355-3
PMCID: PMC5088659

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Source receipt: pubmed, retrieved 7 Sept 2026.

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