Article

Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer’s Disease

2020-10-13

Abstract excerpt

Alzheimer’s disease (AD) brains are characterized by progressive neuron loss and gliosis. Previous studies comparing AD versus control using bulk brain tissue samples have not considered cell composition changes in AD brains that can cause transcriptional changes not due to transcriptional regulation.Using five large transcriptomic datasets, we mined conserved gene co-expression network modules, and applied differ...

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Literature Corpus work: a49a0b50-5ea2-56fe-a635-455bd3a09a5e
DOI: 10.21203/rs.3.rs-92026/v1

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