Article

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

2022-01-11

Abstract excerpt

Dysregulation of gene expression in Alzheimer’s disease (AD) remains elusive, especially at the cell type level. Gene regulatory network, a key molecular mechanism linking transcription factors (TFs) and regulatory elements to govern target gene expression, can change across cell types in the human brain and thus serve as a model for studying gene dysregulation in AD. However, it is still challenging to understand...

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Literature Corpus work: 36ee1053-926e-5aa3-83f5-911d4a7818d5
DOI: 10.1101/2022.01.09.475548

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