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Article

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.

Developmental cell - 1 Apr 2004

Hertweck Maren, Göbel Christine, Baumeister Ralf

Abstract excerpt

The DAF-2 insulin receptor-like signaling pathway controls metabolism, development, longevity, and stress response in C. elegans. Here we show that SGK-1, the C. elegans homolog of the serum- and glucocorticoid-inducible kinase SGK, acts in parallel to the AKT kinases to mediate DAF-2 signaling. Loss of sgk-1 results in defective egg-laying, extended generation time, increased stress resistance, and an extension...

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PMID: 15068796
DOI: 10.1016/s1534-5807(04)00095-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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