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Article

Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans.

Nature communications - 27 Jul 2021

Li Wen-Jun, Wang Chen-Wei, Tao Li, Yan Yong-Hong, Zhang Mei-Jun, Liu Ze-Xian, Li Yu-Xin, Zhao Han-Qing, Li Xue-Mei, He Xian-Dong, Xue Yu, Dong Meng-Qiu

Abstract excerpt

Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic analysis of wild-type and three IIS mutant Caenorhabditis elegans strains. We quantify more than 15,000...

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Identifiers

PMID: 34315882
DOI: 10.1038/s41467-021-24816-z
PMCID: PMC8316574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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