Article
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
Cell metabolism - 4 May 2011
Takahashi Yuta, Daitoku Hiroaki, Hirota Keiko, Tamiya Hiroko, Yokoyama Atsuko, Kako Koichiro, Nagashima Yusuke, Nakamura Ayumi, Shimada Takashi, Watanabe Satoshi, Yamagata Kazuyuki, Yasuda Kayo, Ishii Naoaki, Fukamizu Akiyoshi
Abstract excerpt
Arginine methylation is a widespread posttranslational modification of proteins catalyzed by a family of protein arginine methyltransferases (PRMTs). It is well established that PRMTs are implicated in various cellular processes, but their physiological roles remain unclear. Using nematodes with a loss-of-function mutation, we show that prmt-1, the major asymmetric arginine methyltransferase, is a positive...
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